By PANTANOWITZ LIRON, Pam Michelow, Walid E. Khalbuss
Cytopathology of Infectious ailments is the 1st ebook of its style to concentration totally at the cytopathology of infectious illnesses. It includes all the pertinent information regarding the cytology of infectious ailments and microorganisms and may function a fantastic convenient reference. This special quantity covers the cytomorphology of assorted microorganisms and the host reactions they elicit, and in addition comprises an replace on advances within the box. Newly well-known infections equivalent to the hot discovery of the Merkel phone Polyomavirus (MCV) are integrated, in addition to the application of latest immunostains (e.g. CM2B4 for MCV) and the function of molecular ideas that help in the id, category or even quantification of microorganisms. every one bankruptcy is succinctly written and concisely referenced with key released articles and assets. the amount contains functional guidelines, worthy diagnostic standards, differential diagnoses and power pitfalls. Many colour photographs of excessive answer that illustrate microorganisms (e.g. branching hyphae) and host reactions (e.g. viral cytopathic influence) are incorporated all through. correct tables with diagrams that supply speedy reference courses are included. Cytopathology of Infectious illnesses will function a worthy reference instrument for cytopathologists, anatomical/clinical pathologists, cytotechnologists, pathology citizens and cytopathology fellows.
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Additional info for Cytopathology of Infectious Diseases
12. Crystal formation in Aspergillus infection (Diff-Quik stain, high magnification; Inset: polarization microscopy, high magnification). Acute inflammatory cells and necrotic debris with fungal hyphal elements showing narrow-angle branching (left) associated with calcium oxalate crystals (right). Differential Diagnosis ●● ●● ●● Calcium oxalate crystals: Aspergillus spp. Charcot-Leyden crystals: Eosinophilic inflammation (allergy, asthma, parasites) Other crystals or foreign material Ancillary Studies ●● ●● Special stains (PAS, GMS) for fungal elements Fungal culture for Aspergillus spp.
Granulomatous inflammation with neutrophils: M. tuberculosis, cat scratch disease, fat necrosis. 18 ●● ●● ●● ●● ●● 3. Host Reactions to Infection Granulomas associated with malignancy: Lymphoma, seminoma, squamous cell carcinoma. Xanthogranulomas (see uncommon host reactions). Malakoplakia (see uncommon host reactions). , spindle cell melanoma). Pitfall: False positive diagnoses due to overcalling granulomas as malignancy, particularly in cases of necrotizing granulomas. 2) Fig. 3. Multinucleated foreign body-type giant cell (Diff-Quik stain, high magnification).
Host Reactions to Infection Clinically it presents as a paradoxical worsening of disease or pre-existing infection in HIV patients, shortly after starting antiretroviral treatment. This may be a life-threatening condition. Cytomorphologic Features ●● ●● Marked florid granulomatous inflammation or other inflammatory response. Microorganisms may not be identified at the site of inflammation. Differential Diagnosis ●● Newly acquired infection Ancillary Studies ●● ●● ●● Concomitant drop in HIV levels with improvement in CD4 cell count Special stains and/or immunostains for organisms Microbial cultures Hemophagocytosis and Emperipolesis ●● ●● ●● ●● Hemophagocytosis is the ingestion and often destruction of blood cells by macrophages.