Download Cholesterol Homeostasis: Methods and Protocols by Ingrid C. Gelissen, Andrew J. Brown PDF

By Ingrid C. Gelissen, Andrew J. Brown

This quantity offers cutting-edge innovations for learning a number of features of ldl cholesterol homeostasis, together with its uptake, synthesis and efflux from the mobilephone, in addition to its trafficking in the mobile. Chapters additionally hide ideas for learning the law of ldl cholesterol homeostasis at either the transcriptional and post-translational degrees, in addition to learning the membrane topology and constitution of cholesterol-related proteins. Written within the hugely winning Methods in Molecular Biology series layout, chapters contain introductions to their respective themes, lists of the required fabrics and reagents, step by step, easily reproducible laboratory protocols, and pointers on troubleshooting and fending off identified pitfalls.

Authoritative and functional, Cholesterol Homeostasis: tools and Protocols aims to supply key thoughts in tackling the research of ldl cholesterol homeostasis.

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Sample text

Although the cholesterol-dependent function for several proteins and peptides has been reported, the molecular details and specificity of their interaction are still emerging. Recent technical advancements, and ready availability of multiple agents for modulation of membrane cholesterol and close structural analogs of cholesterol, have made it possible to delineate the structural stringency associated with the interaction of cholesterol with membrane proteins and receptors. In this article, we provide an overview of the approaches, particularly utilizing structural analogs of cholesterol, for addressing structural stringency of cholesterol for the function of membrane proteins, with special emphasis on stereoisomers of cholesterol.

Levitan I, Singh DK, Rosenhouse-Dantsker A (2014) Cholesterol binding to ion channels. Chattopadhyay A (2014) GPCRs: lipid-­ dependent membrane receptors that act as drug targets. Adv Biol 2014:143023 10. Paila YD, Chattopadhyay A (2009) The function of G-protein coupled receptors and membrane cholesterol: specific or general interaction? Lee AG (2011) Biological membranes: the importance of molecular detail. Trends Biochem Sci 36:493–500 12. Paila YD, Tiwari S, Chattopadhyay A (2009) Are specific nonannular cholesterol binding sites present in G-protein coupled receptors?

Chattopadhyay A (2014) GPCRs: lipid-­ dependent membrane receptors that act as drug targets. Adv Biol 2014:143023 10. Paila YD, Chattopadhyay A (2009) The function of G-protein coupled receptors and membrane cholesterol: specific or general interaction? Lee AG (2011) Biological membranes: the importance of molecular detail. Trends Biochem Sci 36:493–500 12. Paila YD, Tiwari S, Chattopadhyay A (2009) Are specific nonannular cholesterol binding sites present in G-protein coupled receptors? Simmonds AC, East JM, Jones OT, Rooney EK, McWhirter J, Lee AG (1982) Annular and non-annular binding sites on the (Ca2+ + Mg2+)-ATPase.

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